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Novel 1',1'-chain substituted Delta(8)-tetrahydrocannabinols
Demetris P Papahatjis1, Spyros P Nikas, Thanos Andreou
1Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, 48 Vass. Constantinou, Athens 116-35, Greece.
Bioorganic & Medicinal Chemistry Letters
|November 22, 2002
Abstract:
1',1'-Cyclopropyl side chain substituents enhance the affinities of Delta(8)-tetrahydrocannabinol and respective cannabidiol analogues for the CB1 and CB2 cannabinoid receptors. The results support the hypothesis for a subsite within CB1 and CB2 binding domain at the level of the benzylic side chain carbon in the tetrahydrocannabinol and cannabidiol series. Efficient procedures for the synthesis of 1',1'-cyclopropyl analogues are described.