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Lactobacilli as live vaccine delivery vectors: progress and prospects
1Lactrys, TNO Prevention and Health, Division of Immunological and Infectious Diseases, PO Box 2301 CE, Leiden, The Netherlands. jfml.seegers@pg.tno.nl
Trends in Biotechnology
|November 22, 2002
Summary
Lactobacilli can modulate immune responses and serve as oral vaccine carriers. Research shows potential for using these bacteria with antigens beyond tetanus toxin fragment C for live vaccine development.
Area of Science:
- Immunology
- Microbiology
- Vaccinology
Background:
- Lactobacilli exhibit strain-dependent immunomodulatory effects.
- This capacity positions Lactobacillus as a promising oral vaccine carrier.
- Current knowledge primarily uses tetanus toxin fragment C (TTFC) as a model antigen.
Purpose of the Study:
- To explore the potential of lactobacilli as live vaccine carriers for antigens other than TTFC.
- To leverage understanding of the immune system and biotechnological advancements for vaccine development.
Main Methods:
- Utilizing Lactobacillus strains for their immunomodulatory properties.
- Applying modern cloning and expression techniques for antigen delivery.
- Investigating immune responses to novel antigens delivered by lactobacilli.
Main Results:
- Accumulating evidence supports the strain-specific immune influence of lactobacilli.
- Lactobacillus demonstrates significant potential as a carrier for oral vaccines.
- Advancements facilitate the use of diverse antigens beyond TTFC.
Conclusions:
- Lactobacilli are viable candidates for developing live oral vaccines.
- The use of lactobacilli as vaccine carriers is a realistic prospect.
- Further research can expand the application of lactobacilli in vaccinology.