Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Microbicides--evaluating multiple formulations of C31G.

R Bax¹, K Douville, D McCormick

¹Biosyn, Inc, 1800 Byberry Road, Building 13, Huntingdon Valley, PA 19006, USA. rbax@biosyn-inc.com

|November 22, 2002

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A consensus statement on a National Competency Framework for training and assessment of knowledge and skills in diabetes technologies, including hybrid closed loop (HCL), insulin pump systems, and continuous glucose monitoring (CGM) devices.

Diabetic medicine : a journal of the British Diabetic Association·2026

Same author

<sup>81</sup>Kr dating of 1 kg Antarctic ice.

Nature communications·2025

Same author

Longitudinal Speech Outcome at 5 and 10 Years in UCLP: Influence of Speech Therapy and Secondary Velopharyngeal Surgery.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association·2024

Same author

User-centered development process of an operating interface to couple a robotic glove with a virtual environment to optimize hand rehabilitation following a stroke.

Journal of rehabilitation and assistive technologies engineering·2023

Same author

Diverged subpopulations in tropical Urochloa (Brachiaria) forage species indicate a role for facultative apomixis and varying ploidy in their population structure and evolution.

Annals of botany·2022

Same author

Characterization of buried interfaces using Ga Kα hard X-ray photoelectron spectroscopy (HAXPES).

Faraday discussions·2022

A new microbicide gel, 1.0% C31G, shows promise for preventing sexually transmitted diseases (STDs) and HIV. This 3-day trial found it to be the safest and most acceptable formulation tested.

Area of Science:

Microbiology
Infectious Diseases
Drug Development

Background:

A critical need exists for effective microbicides to combat the global spread of sexually transmitted diseases (STDs), including HIV.
Currently, no approved microbicides are available to prevent STD and HIV transmission.

Purpose of the Study:

To evaluate the safety and acceptability of various microbicide formulations, including C31G, in a short-term clinical trial.
To compare the tolerability and acceptance of different gel formulations for potential microbicide use.

Main Methods:

A 3-day, once-daily dosing clinical trial was conducted to assess multiple microbicide formulations.
A scoring algorithm, based on subject-reported symptoms and observed signs, was used to evaluate safety and acceptance.

Related Experiment Videos

Formulation differences were analyzed for their impact on microbicide tolerance and acceptability.

Main Results:

Significant differences in tolerance and acceptability were observed among the tested formulations.
The 1.0% C31G co-polymer gel demonstrated superior tolerability and acceptability compared to other formulations.
Results were consistent with a previous 7-day trial involving two of the formulations (1.2% HEC gel, 2.0% N-9).

Conclusions:

Formulation characteristics significantly influence the tolerance and acceptability of microbicides.
The 1.0% C31G co-polymer gel is the most promising candidate for further development in longer trials.
The 3-day trial design is validated as an effective method for assessing microbicide formulations.