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New acylated triterpene saponins from Silene fortunei that modulate lymphocyte proliferation
Ghezala Gaidi1, Tomofumi Miyamoto, Véronique Laurens
1Laboratoire de Pharmacognosie, Unité de Molécules d'Intérêt Biologique, JE 2244, Faculté de Pharmacie, Université de Bourgogne, 7, Bd Jeanne d'Arc, BP 87900, 21079 Dijon Cedex, France.
Abstract:
Three new acylated triterpene saponins 1-3, with a quillaic acid as aglycon, were isolated from the roots of Silene fortunei together with a known phytoecdysteroid (20-hydroxyecdysone). The compounds were characterized mainly by a combination of 2D NMR techniques, mass spectrometry, and chemical methods. Saponins 1-3, jenisseensosides C and D (4, 5), and 6 (deacylated form of 2/3 and 4/5) were found to stimulate the proliferation of the Jurkat tumor cell lines at low concentration. At high concentration, 2/3 and 4/5 inhibited the proliferation of the cells and suggested the induction of apoptosis.