Coordination chemistry of tripyridinedimethane
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Updated: Sep 28, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Andrei N Vedernikov1, John C Huffman, Kenneth G Caulton
1Department of Chemistry and Molecular Structure Center, Indiana University, Bloomington, Indiana 47405-7102, USA.
Abstract:
The ligand tripyridinedimethane (tpdm), consisting of three pyridine residues linked at their ortho carbons by two CH(2) groups, is shown to be a sterically flexible ligand capable of binding in a meridional arrangement in trigonal bipyramidal (tpdm) Cu(II)Cl(2) but binding in a facial arrangement in tetrahedral (tpdm) Cu(I)Cl. Nucleophilic substitution of chloride by (t)BuO(-) and PhC[triple bond]C(-) is possible, and deprotonation of the acidic benzylic protons does not take place because the resulting carbanion cannot achieve coplanarity with the aryl rings. RhCl(3) forms, with tpdm in boiling methanol, a 1:1 kinetic mixture of fac- and mer-isomers RhCl(3)(tpdm). The former isomerizes slowly at RT (room temperature) in DMSO solution into the latter with Rh-N bond dissociation as the rate-determining step.
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