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Studying Chronic Exposure of Mice to Ultraviolet B Radiation
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Studying Chronic Exposure of Mice to Ultraviolet B Radiation

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Mechanisms underlying UV-induced immune suppression: implications for sunscreen design

Stephen E Ullrich1, Margaret L Kripke, Honnavara N Ananthaswamy

  • 1Department of Immunology, University of Texas M. D. Anderson Cancer Center, Texas Medical Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. sullrich@mdanderson.org

Experimental Dermatology
|November 26, 2002
PubMed

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Mutations01:35

Mutations

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Mutations

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Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
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Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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Nucleotide Excision Repair

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