Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antibody-based diagnostic for 'refractory' periodontitis.

M Levine1, S LaPolla, W L Owen

  • 1Department. Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. Martin.levine@ouhsc.edu

Journal of Clinical Periodontology
|November 26, 2002
PubMed
Summary

An elevated IgG antibody response to lysine decarboxylase (HKL-Ab) accurately predicts treatment outcomes in refractory chronic periodontitis patients. This finding aids in identifying individuals likely to benefit from specific therapeutic interventions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different core promoters possess distinct regulatory activities in the Drosophila embryo.

Genes & development·1998
Same author

In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats.

The Journal of pharmacology and experimental therapeutics·1998
Same author

Pulmonary toxicity of high-dose chemotherapy for breast cancer: a non-invasive approach to diagnosis and treatment.

Bone marrow transplantation·1998
Same author

Ascorbate recycling in human neutrophils: induction by bacteria.

Proceedings of the National Academy of Sciences of the United States of America·1998
Same author

The occurrence of subsequent malignancy in patients presenting with deep vein thrombosis: results from a historical cohort study.

Thrombosis and haemostasis·1998
Same author

Pharmacokinetic model of ascorbic acid in healthy male volunteers during depletion and repletion.

Pharmaceutical research·1997

Area of Science:

  • Periodontology
  • Immunology
  • Microbiology

Background:

  • Chronic periodontitis affects 10-15% of US adults, with a subset exhibiting refractory disease.
  • Elevated lysine decarboxylase activity in sulcular microbiota is linked to refractory periodontitis.
  • Accurate prediction of refractory cases is crucial for effective treatment strategies.

Purpose of the Study:

  • To determine if elevated IgG antibody response to lysine decarboxylase (HKL-Ab) can predict refractory chronic periodontitis.
  • To assess the predictive value of HKL-Ab, alone or combined with other antibodies and clinical factors.
  • To improve diagnostic accuracy for identifying patients with treatment-resistant periodontitis.

Main Methods:

  • Chronic periodontitis patients underwent scaling and root planing (SRP) with regular follow-ups.

Related Experiment Videos

  • Refractory status was defined by recurrent attachment loss after initial treatment.
  • Logistic regression models incorporating baseline clinical measurements and specific antibody responses were used for prediction.

    • Main Results:

    • Antibody to a peptide portion of lysine decarboxylase (HKL-Ab) and bleeding on probing (BOP) predicted attachment loss post-therapy.
    • IgG antibodies to Actinomyces spp. (A-Ab) and streptococcal d-alanyl glycerol lipoteichoic acid (S-Ab) were correlated in refractory patients.
    • A logistic regression model using HKL-Ab, other antibodies, and clinical factors achieved 86% accuracy in predicting refractory or successfully treated patients.

    Conclusions:

    • Elevated IgG antibody response to lysine decarboxylase (HKL-Ab) accurately predicts therapeutic outcomes in moderate periodontitis.
    • This immunological marker can assist in identifying patients likely to be refractory to standard periodontitis therapy.
    • Further research can refine predictive models for personalized periodontitis management.