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Positional information: knowing where you are in a limb
1MRC Centre for Developmental Neurobiology, King's College London, 4th floor New Hunt's House, Guy's Campus, London Bridge, SE1 1UL, London, UK. malcolm.maden@kcl.ac.uk
Current Biology : CB
|November 26, 2002
Abstract:
In the regenerating amphibian limb, positional information has traditionally been considered in terms of short-range cell-cell interactions, not long-range diffusion gradients. A molecule discovered in a differential screen of regenerating limbs turns out to be precisely such a cell surface component, the newt ortholog of mouse CD59.