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Recirculation peritoneal dialysis with sorbent Redy cartridge.
Nephron
|January 1, 1976
Summary
Recirculating peritoneal dialysis (RPD) using the Redy cartridge offers superior urea and creatinine clearance compared to intermittent peritoneal dialysis (IPD). This efficient method may reduce overall dialysis treatment time.
Area of Science:
- Nephrology
- Biomedical Engineering
Background:
- Sorbent regeneration of peritoneal dialysate enables small-volume dialysis.
- Intermittent peritoneal dialysis (IPD) and recirculating peritoneal dialysis (RPD) are methods for dialysis.
Purpose of the Study:
- To compare solute clearance for urea and creatinine between IPD and RPD using the Redy cartridge in dogs.
- To evaluate the efficiency of RPD at varying flow rates.
Main Methods:
- Ten dogs were used to compare solute clearance (CU and CCr) in IPD and RPD.
- RPD utilized two silastic peritoneal catheters, a Sarns roller pump, and the Redy cartridge.
- Experiments were conducted at flow rates ranging from 66 to 250 ml/min.
Main Results:
- RPD demonstrated higher urea and creatinine clearance than IPD at comparable flow rates (p>0.01).
- At higher flow rates (150-250 ml/min), RPD showed 2-3 times greater solute removal than IPD.
- The Redy cartridge effectively removed urea and creatinine but not glucose after saturation; serum sodium increased slightly with RPD.
Conclusions:
- RPD with the Redy cartridge is more efficient than IPD, likely due to continuous exchange.
- RPD is mechanically simple, efficient, and has the potential to shorten peritoneal dialysis duration.