New compounds by combining "modern" genomics and "old-fashioned" mutasynthesis

Exploring shikimate pathway enzyme diversity for engineering of glycopeptide antibiotic biosynthesis.

Metabolic engineering·2026

CRISPR-Cas in actinomycetes: still a lot to be discovered.

microLife·2025

Gene sco1417 encodes a positive regulator of the de novo biosynthesis of pyridoxal 5'-phosphate (vitamin B6) in Streptomyces coelicolor M145.

BMC microbiology·2025

Unveiling the substrate specificity of the ABC transporter Tba and its role in glycopeptide biosynthesis.

iScience·2025

GlnA3<i></i> is able to glutamylate spermine but it is not essential for the detoxification of spermine in <i>Mycobacterium tuberculosis</i>.

Journal of bacteriology·2025

Clostridium perfringens chitinases, key enzymes during early stages of necrotic enteritis in broiler chickens.

PLoS pathogens·2024

DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells.

Chemistry & biology·2015

Differential Regulation of Specific Sphingolipids in Colon Cancer Cells during Staurosporine-Induced Apoptosis.

Chemistry & biology·2015

Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα.

Chemistry & biology·2015

Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery.

Chemistry & biology·2015

Vitamin C as Cancer Destroyer, Investigating Sulfhydration, and the Variability in CFTR Interactome.

Chemistry & biology·2015

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

Chemistry & biology·2015

Generalizable structure-function covariation predictive of antidepressant response revealed by target-oriented multimodal fusion.

Nature. Mental health·2026

Integrated docking-molecular dynamics, ADME-toxicity profiling, and transcriptomic validation identify oroxylin a as a TLR7-targeting flavonoid candidate in systemic lupus erythematosus.

Frontiers in chemistry·2026

Novel seleno-ureido hybrids targeting head and neck cancer and beyond: design, synthesis, and apoptosis-mediated anticancer evaluation.

RSC advances·2026

Can Large Language Models Translate MS/MS into Molecular Caption?

Analytical chemistry·2026

Synthesis, Characterization, and Biological Evaluation of Co(II), Cu(II), and Ni(II) Complexes With 2,2'-Bipyridine-5,5'-Dicarboxamide Ligands: Antibacterial and Enzyme Inhibition Studies.

ChemistryOpen·2026

Evaluation of deep learning architectures for predicting ligand interactions with neurologically relevant GPCRs.

Journal of cheminformatics·2026

Related Experiment Videos

New compounds by combining "modern" genomics and "old-fashioned" mutasynthesis

Related Concept Videos

Exploring shikimate pathway enzyme diversity for engineering of glycopeptide antibiotic biosynthesis.

CRISPR-Cas in actinomycetes: still a lot to be discovered.

Gene sco1417 encodes a positive regulator of the de novo biosynthesis of pyridoxal 5'-phosphate (vitamin B6) in Streptomyces coelicolor M145.

Unveiling the substrate specificity of the ABC transporter Tba and its role in glycopeptide biosynthesis.

GlnA3<i></i> is able to glutamylate spermine but it is not essential for the detoxification of spermine in <i>Mycobacterium tuberculosis</i>.

Clostridium perfringens chitinases, key enzymes during early stages of necrotic enteritis in broiler chickens.

DIVERSE System: De Novo Creation of Peptide Tags for Non-enzymatic Covalent Labeling by In Vitro Evolution for Protein Imaging Inside Living Cells.

Differential Regulation of Specific Sphingolipids in Colon Cancer Cells during Staurosporine-Induced Apoptosis.

Synthetic Peptides as cGMP-Independent Activators of cGMP-Dependent Protein Kinase Iα.

Unraveling the B. pseudomallei Heptokinase WcbL: From Structure to Drug Discovery.

Vitamin C as Cancer Destroyer, Investigating Sulfhydration, and the Variability in CFTR Interactome.

Human ISPD Is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.

Generalizable structure-function covariation predictive of antidepressant response revealed by target-oriented multimodal fusion.

Integrated docking-molecular dynamics, ADME-toxicity profiling, and transcriptomic validation identify oroxylin a as a TLR7-targeting flavonoid candidate in systemic lupus erythematosus.

Novel seleno-ureido hybrids targeting head and neck cancer and beyond: design, synthesis, and apoptosis-mediated anticancer evaluation.

Can Large Language Models Translate MS/MS into Molecular Caption?

Synthesis, Characterization, and Biological Evaluation of Co(II), Cu(II), and Ni(II) Complexes With 2,2'-Bipyridine-5,5'-Dicarboxamide Ligands: Antibacterial and Enzyme Inhibition Studies.

Evaluation of deep learning architectures for predicting ligand interactions with neurologically relevant GPCRs.

Related Experiment Videos

New compounds by combining "modern" genomics and "old-fashioned" mutasynthesis

Related Concept Videos

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