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Changes in pyridoxal kinase immunoreactivity in the gerbil hippocampus following spontaneous seizure
Tae Cheon Kang1, Seung Kook Park, In Koo Hwang
1Department of Anatomy, College of Medicine, College of Life Science, Hallym University, Kangwon-Do, Chunchon, South Korea. tckang@hallym.ac.kr
Abstract:
To identify the roles of pyridoxal kinase (PLK) in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PLK expression in the gerbil hippocampus was conducted. PLK immunoreactivity in a pre-seizure group of seizure sensitive (SS) gerbils was more strongly detected than that in a seizure resistant (SR) group. The density of PLK immunoreactivity in a 30-min postictal group was significantly lower than that of a pre-seizure group. In a 12 h postictal group, PLK immunodensity recovered to pre-seizure level. The over-expression of PLK in the hippocampus of pre-seizure SS gerbils suggests that PLP play an important role in the modulation of GAD activity and GABA reuptake as mediated by membrane transporter via neurons.