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Chromium-induced toxic hepatitis
Sara Lança1, Amanda Alves, Ana Isabel Vieira
1Hospital Garcia de Orta, Av. Torrado Silva, 2800, Almada, Portugal
European Journal of Internal Medicine
|November 26, 2002
Summary
Chromium polynicotinate, used in an alternative weight-loss plan, may cause toxic hepatitis. Liver damage indicators improved after discontinuing the chromium supplement.
Area of Science:
- Hepatology
- Toxicology
- Nutritional Medicine
Background:
- Alternative medicine weight-reduction regimens are popular.
- Herbal and mineral supplements are often used in these programs.
- Potential toxicity of unregulated supplements requires investigation.
Purpose of the Study:
- To report a clinical case of acute hepatitis.
- To investigate the potential role of chromium polynicotinate in drug-induced liver injury.
- To highlight the importance of considering supplement toxicity in unexplained hepatitis.
Main Methods:
- A clinical case study was conducted.
- Liver biopsy was performed for histopathological examination.
- Hepatic chromium levels were measured.
Main Results:
- The patient presented with acute hepatitis symptoms.
- Liver biopsy confirmed toxic hepatitis.
- Hepatic chromium levels were significantly elevated (>10x normal).
- Symptoms resolved after cessation of chromium polynicotinate.
Conclusions:
- Chromium polynicotinate, when used in alternative weight-reduction regimens, can lead to toxic hepatitis.
- Elevated hepatic chromium levels are indicative of toxicity.
- Discontinuation of the offending agent is crucial for recovery.