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The Nijmegen Hemostasis Assay: Simultaneous Fluorogenic Measurement of Thrombin and Plasmin Generation in a Single Well
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Coagulation: consultative hemostasis

Julie Hambleton1, Lawrence L Leung, Marcel Levi

  • 1Hemostasis and Thrombosis, Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, 94143, USA.

Hematology. American Society of Hematology. Education Program
|November 26, 2002
PubMed

Insights

This review updates clinical hematologists on advances in disseminated intravascular coagulation (DIC) and thrombosis management in hospitalized patients. It covers pathogenic mechanisms, novel therapies for DIC, refractory thrombosis, and hemostatic complications in solid organ transplantation.

Area of Science:

  • Hematology
  • Thrombosis
  • Coagulopathy

Background:

  • Clinical hematologists manage complex coagulopathies in hospitalized patients.
  • Disseminated intravascular coagulation (DIC) and thrombosis present significant inpatient challenges.
  • Hemostasis management in solid organ transplantation requires specialized knowledge.

Purpose of the Study:

  • To provide an update on scientific and clinical advances in DIC.
  • To discuss challenges in inpatient thrombosis management.
  • To review hemostatic complications in solid organ transplantation.

Main Methods:

  • Review of pathogenic mechanisms and novel therapeutic strategies for DIC.
  • Overview of challenging inpatient thrombosis cases, including refractory DVT and mesenteric thrombosis.
  • Examination of hemostatic complications in solid organ transplantation, focusing on liver transplantation.

Main Results:

  • Advances in understanding DIC pathogenesis and novel treatment evaluations, particularly in sepsis.
  • Discussion of refractory thrombosis, PF4/heparin ELISA interpretation, and novel treatments for dialysis catheter thrombosis.
  • Emphasis on coagulopathy in liver transplantation, thrombophilia, drug-induced microangiopathy, and postoperative prophylaxis.

Conclusions:

  • Current understanding and therapeutic strategies for DIC have advanced.
  • Inpatient thrombosis presents complex scenarios requiring tailored management.
  • Effective management of hemostatic complications is crucial for solid organ transplant outcomes.

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