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Tau, where are we now?

Gail V W Johnson1, Craig D C Bailey

  • 1Department of Psychiatry, University of Alabama at Birmingham School of Medicine, 35294-0017, USA. gvwj@uab.edu

Journal of Alzheimer'S Disease : JAD
|November 26, 2002
PubMed
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Tau protein, crucial for neuronal function, is implicated in Alzheimer's disease and other tauopathies. Its abnormal processing leads to neuronal dysfunction and death, highlighting its central role in neurodegeneration.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Tau protein, initially identified as a microtubule-associated protein, is predominantly found in neurons but also plays roles in non-neuronal cells.
  • Tau is the main component of filaments in Alzheimer's disease brains and is central to a class of neurodegenerative diseases known as tauopathies.
  • Mutations in the tau gene are linked to frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), demonstrating tau's role in neuronal dysfunction.

Purpose of the Study:

  • To review recent findings on the normal metabolism and function of tau protein.
  • To explore the abnormal processing and function of tau in Alzheimer's disease and tauopathies.
  • To highlight the significance of tau pathology in both sporadic and familial neurodegenerative conditions.

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Main Methods:

  • Literature review of recent scientific findings.
  • Analysis of studies on tau protein metabolism and function.
  • Examination of research on tau pathology in Alzheimer's disease and tauopathies.

Main Results:

  • Tau protein has essential roles in both neuronal and non-neuronal cells.
  • Abnormal tau processing and aggregation are hallmarks of Alzheimer's disease and tauopathies.
  • Tau gene mutations directly cause neurodegenerative diseases like FTDP-17.

Conclusions:

  • Tau protein dysfunction is a key driver of neuronal death in Alzheimer's disease and tauopathies.
  • Understanding normal and abnormal tau function is critical for developing therapeutic strategies.
  • Further research into tau metabolism and pathology is essential for combating neurodegenerative diseases.