Major coronary anomalies in childhood
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Updated: Sep 21, 2026

Analysis of Coronary Vessels in Cleared Embryonic Hearts
Published on: December 7, 2016
Daniël De Wolf1, Tom Vercruysse, Bert Suys
1Department of Paediatric Cardiology, Ghent University Hospital, De Pintelaan 185, 9000 Gent, Belgium. daniel.dewolf@rug.ac.be
Insights
Rare coronary artery anomalies in children, including ALCAPA, fistulas, and stenosis, can be accurately diagnosed using various methods. Prompt treatment for these conditions leads to favorable outcomes.
Area of Science:
- Pediatric Cardiology
- Congenital Heart Disease
- Cardiovascular Imaging
Background:
- Major coronary artery anomalies are infrequent in pediatric populations.
- Understanding diagnostic features and therapeutic strategies is crucial for managing these rare conditions.
Purpose of the Study:
- To evaluate historical, diagnostic, and therapeutic aspects of three coronary artery anomalies in children.
- Focus on abnormal origin of the left coronary artery from the pulmonary artery (ALCAPA), coronary fistula, and coronary stenosis.
Main Methods:
- Retrospective review of 33 pediatric cases with coronary artery anomalies.
- Analysis included patient history, physical examination, ECG, X-ray, echocardiography, and angiography.
- Therapeutic options and patient outcomes were systematically assessed.
Main Results:
- ALCAPA cases exhibited characteristic echocardiographic findings.
- Coronary artery fistulas were identified by murmurs and echocardiographic dilatations.
- Coronary stenosis diagnosis was suggested by specific clinical presentations.
Conclusions:
- Accurate diagnosis of rare pediatric coronary artery anomalies is achievable.
- Early intervention and appropriate therapy are associated with good prognoses.
Unlabelled:
Major coronary artery anomalies are extremely rare in childhood. We wanted to assess the historical and diagnostic features and the therapeutic options of three distinct types of coronary artery anomalies: abnormal origin of the left coronary artery from the pulmonary artery (ALCAPA), coronary fistula and coronary stenosis. In a retrospective study, 33 children with these types of coronary artery disease were identified, 15 with ALCAPA, 12 with fistula and six with coronary stenosis. History, physical examination, ECG, X-ray, echocardiography, angiography, therapy and outcome were reviewed. ALCAPA showed distinct typical echocardiographic characteristics. Coronary artery fistula could be identified by a typical murmur and echocardiographic evidence of coronary dilatations. Coronary stenosis should be suspected by the clinical picture in a specific context.
Conclusion:
rare coronary artery anomalies can be accurately diagnosed in childhood. Timely therapy yields good prognosis.
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