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[Neuropsychological changes in coeliac disease]
A Martínez-Bermejo1, I Polanco
1Servicio de Neuropediatría, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Madrid, Spain. med014988@saludalia.com
Revista De Neurologia
|November 26, 2002
Summary
Coeliac disease, an immune disorder triggered by cereals, can affect the nervous system, causing neurological and psychiatric issues. Early diagnosis and a cereal-free diet are crucial for managing these diverse symptoms.
Area of Science:
- Gastroenterology
- Neurology
- Immunology
Context:
- Coeliac disease is an immune-mediated gastrointestinal disorder.
- It involves intolerance to cereals, leading to intestinal mucosal damage and malabsorption.
- The condition presents a broad spectrum, affecting multiple organs and systems.
Purpose:
- To review studies on the involvement of the nervous system in coeliac disease.
- To highlight the neurological and psychiatric manifestations associated with coeliac disease.
Summary:
- Coeliac disease is linked to a high prevalence of neurological issues like ataxia, headaches, and epilepsy.
- Psychiatric disorders, including behavioral changes, depression, and personality disorders, are also frequently observed.
- Cognitive and learning problems are less common but noted.
Impact:
- Recognizing these non-gastrointestinal symptoms is vital for early diagnosis.
- The pathogenic mechanisms are not fully understood, but biochemical factors like low serotonin may play a role.
- A cereal-free diet is the most effective treatment, emphasizing the importance of early intervention.