Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The dynamics of cell cycle regulation.

John J Tyson1, Attila Csikasz-Nagy, Bela Novak

  • 1Department of Biology, Virginia Polytechnic Institute & State University, Blacksburg 24061, USA. tyson@vt.edu

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|November 26, 2002
PubMed
Summary

This study uses bifurcation diagrams to analyze cell cycle regulation, offering new insights into genome integrity and mutant cell replication dynamics in fission yeast.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: Revisiting Turing's Chemical Basis of Morphogenesis.

Bulletin of mathematical biology·2026
Same author

Revisiting Turing's Chemical Basis of Morphogenesis.

Bulletin of mathematical biology·2026
Same author

Digital twin approaches for interpretable side effect prediction in drug discovery.

Drug discovery today·2026
Same author

Optogenetic control of transition to metamorphosis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Béla Novák (1956-2025) - a legacy of scientific discovery and personal charm.

Journal of cell science·2025
Same author

Editorial: Use of quantitative systems pharmacology pipelines to bridge <i>in vitro</i> and <i>in vivo</i> results in drug discovery.

Frontiers in systems biology·2025

Area of Science:

  • Cell Biology
  • Systems Biology
  • Biophysics

Background:

  • Cell cycle progression relies on intricate protein interaction networks controlling cyclin-dependent kinases.
  • Understanding cell cycle dynamics is crucial for comprehending cell replication and genome integrity.

Purpose of the Study:

  • To explore the qualitative dynamics of cell cycle regulation using analytical tools.
  • To investigate how molecular interactions influence cell replication properties.
  • To analyze the role of checkpoints in genome integrity and abnormal cell cycle regulation in mutants.

Main Methods:

  • Modeling the cell cycle network using nonlinear differential equations.
  • Employing numerical simulations for quantitative analysis.
  • Utilizing bifurcation diagrams for qualitative dynamical insights.

Related Experiment Videos

Main Results:

  • Bifurcation diagrams reveal dynamical organization of the cell cycle.
  • The analysis provides new views on the function of checkpoints in maintaining genome integrity.
  • Abnormal cell cycle regulation in mutants is illuminated through this approach.

Conclusions:

  • Bifurcation analysis is a powerful tool for understanding cell cycle control beyond numerical simulations.
  • This method offers deeper insights into the physiological properties of cell replication.
  • The study demonstrates the utility of bifurcation diagrams in analyzing cell cycle regulation in fission yeast.