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Updated: Sep 28, 2026

Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
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Published on: January 11, 2019

[Apoptosis and its importance in the development and therapy of tumors (review)]

Z Kleibl1, M Raisová, J Novotný

  • 1II. ústav lékarské chemie a biochemie 1. lékarské fakulty Univerzity Karlovy, U nemocnice 5, 128 53 Praha 2, Czech Republic. zdekleje@lf1.cuni.cz

Sbornik Lekarsky
|November 27, 2002
PubMed

Insights

This review explores apoptosis, programmed cell death, and its regulation in maintaining tissue balance. Understanding apoptosis mechanisms is crucial for improving cancer diagnostics and therapies.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Context:

  • Apoptosis is a fundamental biological process crucial for tissue homeostasis.
  • Its dysregulation is implicated in numerous pathologies, including cancer and inflammatory diseases.
  • Understanding apoptosis is vital for predicting and enhancing cancer treatment responses.

Purpose:

  • To review the intricate mechanisms regulating apoptosis.
  • To highlight the role of key proteins like caspases, Bcl-2 family, and p53 in apoptosis.
  • To underscore the significance of apoptosis in oncological diagnostics and therapeutics.

Summary:

  • Apoptosis, or programmed cell death, is characterized by distinct morphological changes and requires the activation of specific proteins, notably caspases.
  • Caspase activation can be triggered extrinsically via death receptors or intrinsically through mitochondrial pathways involving cytochrome c.
  • Proteins such as the Bcl-2 family and p53 play critical roles in modulating apoptotic pathways.

Impact:

  • Enhanced understanding of apoptosis mechanisms provides a stronger basis for developing novel diagnostic and therapeutic strategies in oncology.
  • Insights into apoptosis regulation can lead to improved patient outcomes in cancer treatment.
  • This review consolidates current knowledge on apoptosis, facilitating further research and clinical applications.

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