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Updated: Sep 28, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
Published on: October 14, 2021
[Hypersexuality during use of levodopa]
R A J van Deelen1, M K Rommers, J G Eerenberg
1Afd. Geriatrie, TweeSteden Ziekenhuis, Postbus 90.107, 5000 LA Tilburg.
Abstract:
A 71-year-old single male who was being treated for Parkinson's disease with levodopa, had several episodes of hypersexual behaviour. Home care was terminated for this reason. Family members in particular had problems with his behaviour. It transpired that he was taking more levodopa than prescribed. After explaining the side-effect to the patient and after a special medication box was purchased which could be filled by the family, the patient's hypersexuality disappeared without deterioration of Parkinson's disease. Hypersexuality is a known, though not frequently recognised side-effect of dopaminergic anti-Parkinson therapy, especially levodopa. This side-effect is not life-threatening, but can have an enormous impact on the quality of life of the patient, his or her partner and environment. The mechanism is probably related to the pharmacological action of dopamine.
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