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Inflammatory response to different endodontic irrigating solutions.

M Tanomaru Filho1, M R Leonardo, L A B Silva

  • 1Department of Endodontics, School of Dentistry of Araraquara, University of the State of São Paulo, Araraquara, SP, Brazil.

International Endodontic Journal
|November 27, 2002
PubMed
Summary

Sodium hypochlorite irrigation solution induced significant inflammation and protein leakage in mice. In contrast, chlorhexidine digluconate irrigation did not cause a notable inflammatory response.

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Area of Science:

  • Biomedical Science
  • Inflammation Research
  • Surgical Irrigation

Background:

  • Peritoneal irrigation solutions are used in various surgical procedures.
  • Understanding the inflammatory potential of these solutions is crucial for patient safety.

Purpose of the Study:

  • To assess the inflammatory response elicited by sodium hypochlorite and chlorhexidine digluconate solutions.
  • To compare the effects of these irrigants against a phosphate-buffered saline control in a murine model.

Main Methods:

  • Sixty mice underwent intra-peritoneal injections of 0.5% sodium hypochlorite, 2.0% chlorhexidine digluconate, or PBS.
  • Inflammatory cell counts and protein leakage were measured at 4, 24, 48 hours, and 7 days post-injection.

Main Results:

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  • Sodium hypochlorite significantly increased neutrophil and mononuclear cell migration and protein leakage.
  • These inflammatory markers were elevated from 48 to 168 hours post-injection for sodium hypochlorite.
  • Chlorhexidine digluconate showed no significant difference compared to the control group.

Conclusions:

  • 0.5% sodium hypochlorite solution triggers a notable inflammatory response in the peritoneal cavity.
  • 2.0% chlorhexidine digluconate solution does not induce a significant inflammatory response.
  • These findings suggest differential inflammatory potentials of common surgical irrigants.