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Updated: Jul 8, 2026
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Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report
Published on: February 12, 2018
Macular hole following photodynamic therapy
Ahmad M Mansour1, Ziad M Husseini, Alex R Schakal
1Department of Ophthalmology, American University of Beirut, Beirut, Lebanon.
Ophthalmic Surgery and Lasers
|November 27, 2002
Summary
Photodynamic therapy for wet age-related macular degeneration can lead to macular hole formation. This complication may stem from choroidal swelling or increased traction after treatment.
Area of Science:
- Ophthalmology
- Retinal Diseases
- Neovascularization
Background:
- Juxtafoveolar choroidal neovascularization (CNV) is a common cause of vision loss.
- Photodynamic therapy (PDT) with verteporfin is a standard treatment for wet age-related macular degeneration.
- Posterior vitreous detachment (PVD) is a common age-related condition affecting the vitreous humor.
Observation:
- A 66-year-old woman with a history of PVD received PDT for juxtafoveolar CNV.
- Twenty days post-PDT, fluorescein angiography revealed CNV regression.
- New onset of a macular hole was observed after PDT.
Findings:
- Macular hole formation occurred subsequent to successful PDT for CNV.
- Potential mechanisms include choroidal swelling causing foveal pit dehiscence.
- Exacerbation of tangential traction or cystoid spaces by focal laser application is also considered.
Implications:
- Clinicians should be aware of macular hole formation as a potential complication of PDT.
- Further research is needed to elucidate the exact mechanisms of PDT-induced macular holes.
- This finding may influence treatment strategies and patient counseling for juxtafoveolar CNV.
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