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Doxycycline toxicity in calves in two feedlots.
1The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel. chk1357@netvision.net.il
Summary
Large doxycycline overdoses in calves led to significant mortality. Cardiovascular toxicity, including pulmonary edema and myocardial damage, was observed, highlighting potential side effects in cattle.
Area of Science:
- Veterinary Medicine
- Toxicology
- Animal Health
Background:
- Doxycycline is a common antibiotic used in livestock.
- Overdosing can lead to unintended toxic effects.
- Assessing drug safety in young animals is crucial.
Observation:
- Two cattle feedlots administered doxycycline at 10 times the therapeutic dosage via milk replacer.
- Clinical signs of toxicity appeared within 2-3 days.
- Mortality rates reached 25% and 27% in the affected herds.
Findings:
- Pathological examination revealed pulmonary edema and myocardial degeneration/necrosis.
- These findings indicate severe cardiovascular toxicity.
- Doxycycline overdose is implicated as the cause of toxicity and mortality.
Implications:
- This study highlights the cardiotoxic potential of doxycycline in cattle, particularly calves.
- It underscores the importance of accurate drug dosing in animal husbandry.
- Findings suggest careful monitoring and risk assessment for doxycycline use in feedlots.