[Xenogenic formation of anodic autoprecipitins before and during cardiopulmonary bypass]

The peculiarities of an inductive phase in an immune response to xenobiotics were studied before and during cardiopulmonary bypass at surgical implantations on heart. It has been determined that an early xenogenic induction of the forming the humoral innate immune receptors-namely the anodic (anionic) autoprecipitins-to the surface component of the cellular membrane, depended on the xenobiotic properties, as well as on the initial immunopathogenic: immunocomplex and immuno adsorptive-processes in the cardiovascurlar system. The intensity of this reaction correlated with both subsequent acute disorders in the blood circulation and reducing the resistance to exogeneous (inter-current) infection in the patients with atherosclerosis and endocardits.