Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Circulating catecholamine levels in human and experimental hypertension.

J de Champlain, L Farley, D Cousineau

    Circulation Research
    |February 1, 1976
    PubMed
    Summary

    Serum catecholamine levels are higher in patients with essential hypertension and in rats with experimental hypertension. This suggests the sympathetic nervous system plays a key role in elevated blood pressure.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The clinical evaluation of hypertension.

    Canadian family physician Medecin de famille canadien·2011
    Same author

    [Not Available].

    Canadian family physician Medecin de famille canadien·2011
    Same author

    [Not Available].

    Canadian family physician Medecin de famille canadien·2011
    Same author

    Treatment of microalbuminuria in hypertensive subjects with elevated cardiovascular risk: results of the IMPROVE trial.

    Kidney international·2007
    Same author

    The kinin B1 receptor antagonist SSR240612 reverses tactile and cold allodynia in an experimental rat model of insulin resistance.

    British journal of pharmacology·2007
    Same author

    Review of a mock research protocol in functional neuroimaging by Canadian research ethics boards.

    Journal of medical ethics·2006

    Area of Science:

    • Biochemistry
    • Physiology
    • Cardiovascular Research

    Background:

    • Elevated serum catecholamines are implicated in hypertension.
    • Accurate measurement of catecholamines is crucial for understanding cardiovascular regulation.

    Purpose of the Study:

    • To adapt and validate a radiometric enzymatic technique for measuring serum catecholamines.
    • To investigate serum catecholamine levels in normotensive and hypertensive individuals, and in a rat model of hypertension.

    Main Methods:

    • Adapted Coyle and Henry's radiometric enzymatic technique for serum catecholamine measurement.
    • Measured serum catecholamines in normotensive subjects, essential hypertension patients, and DOCA-salt hypertensive rats.
    • Correlated catecholamine levels with blood pressure and heart rate.

    Related Experiment Videos

    Main Results:

    • The adapted technique is sensitive (25 pg) and reproducible.
    • Normotensive subjects had average serum catecholamines of 0.218 ng/ml.
    • Essential hypertension patients showed significantly higher levels (average 0.370 ng/ml), with >50% exceeding normotensive ranges.
    • Hypertensive patients with elevated catecholamines had higher blood pressure and heart rate.
    • DOCA-salt hypertensive rats exhibited significantly elevated serum catecholamines.

    Conclusions:

    • The adapted radiometric enzymatic technique provides a sensitive and reproducible method for serum catecholamine measurement.
    • Elevated serum catecholamines are associated with essential hypertension in humans and experimental hypertension in rats.
    • These findings highlight the potential role of the sympathetic nervous system in maintaining elevated blood pressure.