Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Instrumentation for contrast echocardiography: technology and techniques.

Sanjiv Kaul1

  • 1Cardiovascular Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville 22908, USA. sk@virginia.edu

The American Journal of Cardiology
|November 27, 2002
PubMed
Summary

Ultrasound imaging uses microbubbles as contrast agents. Specific ultrasound settings alter microbubbles, enhancing imaging for myocardial perfusion assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deletion of GPR39 Prevents Pulmonary Arterial Hypertension by Attenuating Hypoxia-Induced Aberrant Signaling.

bioRxiv : the preprint server for biology·2026
Same author

15-Hydroxyeicosatetraenoic Acid and GPR39 Together Orchestrate Coronary Autoregulation: A Comprehensive Metabolomic Analysis.

bioRxiv : the preprint server for biology·2026
Same author

Selective Pharmacological Blockade of GPR39 Markedly Reduces No Reflow and Infarct Volumes in a Rat Model of Acute Myocardial Infarction.

bioRxiv : the preprint server for biology·2026
Same author

Identification of Novel and Selective GPR39 Receptor Antagonists for the Treatment of Acute Myocardial Ischemia.

ChemMedChem·2025
Same author

The role of transient receptor potential melastatin channels in compressive force-induced contraction of primary cardiac pericytes.

Physiological reports·2025
Same author

Metabolomics of repetitive myocardial stunning in chronic multivessel coronary artery stenosis: Effect of non-selective and selective β1-receptor blockers.

The Journal of physiology·2024

Area of Science:

  • Medical Imaging
  • Ultrasound Technology
  • Cardiovascular Diagnostics

Background:

  • Contrast echocardiography utilizes ultrasound to interact with microbubbles, altering their properties.
  • Microbubble behavior (oscillation to disruption) depends on ultrasound's mechanical index and microbubble characteristics.
  • These interactions generate unique ultrasound backscatter signals distinct from tissue signals.

Purpose of the Study:

  • To explain how ultrasound mechanical index influences microbubble contrast agents.
  • To highlight the exploitation of microbubble signal alterations for enhanced imaging.
  • To demonstrate the capability of these techniques for online myocardial perfusion assessment.

Main Methods:

  • Investigating the effects of varying mechanical index on microbubble contrast agents.

Related Experiment Videos

  • Analyzing microbubble dimensions, shell, and gas properties influencing mechanical index thresholds.
  • Developing signal-processing techniques to differentiate microbubble signals from tissue signals.

    • Main Results:

    • Ultrasound mechanical index can induce microbubble oscillations or disruption, dependent on agent properties.
    • Signal processing enhances the signal-to-noise ratio, isolating microbubble signals.
    • Online assessment of myocardial perfusion is enabled by these advanced imaging techniques.

    Conclusions:

    • Contrast echocardiography's unique interaction between ultrasound and microbubbles allows for targeted imaging.
    • Tailoring mechanical index and signal processing optimizes microbubble visualization.
    • This technology significantly advances the clinical assessment of myocardial perfusion.