Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evolving applications for contrast ultrasound.

Jonathan R Lindner1

  • 1Cardiac Imaging Center, Cardiovascular Division, University of Virginia School of Medicine, Charlottesville, USA. jlindner@virginia.edu

The American Journal of Cardiology
|November 27, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal PET Defines a 'Goldilocks' Thermal Window for Focused Ultrasound Ablation and Immunotherapy Combinations.

bioRxiv : the preprint server for biology·2026
Same author

Mosaic Loss-of-Y Chromosome in Men Is Associated With Aortic Enlargement But Not Aortic Stenosis.

JACC. Advances·2026
Same author

Beyond a Marker: The Long and Short of the PR Interval in Atrial Remodeling.

JACC. Clinical electrophysiology·2026
Same author

A single dose of i.v. iron induces cardiac ferroptosis in murine cardiometabolic heart failure.

JCI insight·2026
Same author

Turbulent Times in Research Funding: ASE's Response to the Challenge.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography·2025
Same author

VEGFR2 blockade converts thermally ablative focused ultrasound into a potent driver of T cell-dependent anti-tumor immunity.

bioRxiv : the preprint server for biology·2025

Site-targeted microbubbles enable noninvasive molecular imaging and targeted drug/gene delivery via ultrasound. This review covers microbubble design strategies and their emerging therapeutic applications for enhanced disease visualization and treatment.

Area of Science:

  • Biomedical Engineering
  • Diagnostic Imaging
  • Molecular Imaging

Background:

  • Contrast-enhanced ultrasound (CEUS) applications are expanding beyond perfusion imaging.
  • Site-targeted microbubbles are being developed to bind to specific disease markers.
  • This allows for noninvasive imaging of molecular and cellular processes in diseased tissues.

Purpose of the Study:

  • To review strategies for designing site-targeted microbubbles.
  • To discuss early experiences with molecular imaging using targeted microbubbles.
  • To explore the therapeutic potential of microbubbles for drug and gene delivery.

Main Methods:

  • Review of current research on site-targeted microbubble design.
  • Analysis of early clinical and preclinical data on molecular imaging with microbubbles.

Related Experiment Videos

  • Examination of therapeutic applications, including drug/gene packaging and ultrasound-mediated delivery.

    • Main Results:

    • Targeted microbubbles can accumulate in diseased tissue, enabling molecular imaging.
    • Microbubbles can be engineered to carry therapeutic payloads (drugs or genes).
    • Ultrasound-mediated microbubble destruction facilitates focal release and extravascular delivery of agents.

    Conclusions:

    • Site-targeted microbubbles represent a significant advancement in noninvasive molecular imaging.
    • Microbubbles offer a promising platform for targeted ultrasound-mediated therapy.
    • Further research is expected to expand clinical applications in both diagnostics and therapeutics.