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Xanthelasma and hyperlipoproteinaemia
Clinica Chimica Acta; International Journal of Clinical Chemistry
|January 16, 1976
Summary
Xanthelasma is linked to hyperlipoproteinaemia, particularly Type II. Low cholesterol diets can reverse high blood lipids but do not affect xanthelasma plaques.
Area of Science:
- Dermatology
- Cardiovascular Medicine
- Metabolic Disorders
Background:
- Xanthelasma is a common skin condition.
- Hyperlipoproteinaemia is a significant risk factor for cardiovascular disease.
- The relationship between xanthelasma and specific types of hyperlipoproteinaemia requires further investigation.
Purpose of the Study:
- To investigate the prevalence of hyperlipoproteinaemia in patients with xanthelasma.
- To determine the effectiveness of low cholesterol diets in managing hyperlipoproteinaemia in these patients.
- To assess the impact of dietary interventions on xanthelasma plaque regression.
Main Methods:
- Ninety-eight female patients with xanthelasma were screened for hyperlipoproteinaemia.
- Lipid profiles were analyzed to identify abnormalities, specifically Type II hyperlipoproteinaemia.
- Patients with hyperlipoproteinaemia were placed on low cholesterol diets for nine months.
Main Results:
- Over half of the patients (55.1%) exhibited signs of hyperlipoproteinaemia.
- A significant majority of those with hyperlipoproteinaemia (77.8%) had the Type II abnormality.
- Low cholesterol diets successfully reversed hyperlipidaemia in most patients within nine months, maintaining normal lipid levels.
- Dietary intervention did not lead to any regression of xanthelasma plaques.
Conclusions:
- Xanthelasma is a potential indicator of underlying hyperlipoproteinaemia, especially Type II.
- Dietary management is effective in controlling hyperlipoproteinaemia associated with xanthelasma.
- Low cholesterol diets do not resolve existing xanthelasma lesions, suggesting a need for separate treatment approaches for the skin manifestation.