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Xanthelasma and hyperlipoproteinaemia.

F D Dean

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |January 16, 1976
    PubMed
    Summary

    Xanthelasma is linked to hyperlipoproteinaemia, particularly Type II. Low cholesterol diets can reverse high blood lipids but do not affect xanthelasma plaques.

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    Area of Science:

    • Dermatology
    • Cardiovascular Medicine
    • Metabolic Disorders

    Background:

    • Xanthelasma is a common skin condition.
    • Hyperlipoproteinaemia is a significant risk factor for cardiovascular disease.
    • The relationship between xanthelasma and specific types of hyperlipoproteinaemia requires further investigation.

    Purpose of the Study:

    • To investigate the prevalence of hyperlipoproteinaemia in patients with xanthelasma.
    • To determine the effectiveness of low cholesterol diets in managing hyperlipoproteinaemia in these patients.
    • To assess the impact of dietary interventions on xanthelasma plaque regression.

    Main Methods:

    • Ninety-eight female patients with xanthelasma were screened for hyperlipoproteinaemia.
    • Lipid profiles were analyzed to identify abnormalities, specifically Type II hyperlipoproteinaemia.
    • Patients with hyperlipoproteinaemia were placed on low cholesterol diets for nine months.

    Main Results:

    • Over half of the patients (55.1%) exhibited signs of hyperlipoproteinaemia.
    • A significant majority of those with hyperlipoproteinaemia (77.8%) had the Type II abnormality.
    • Low cholesterol diets successfully reversed hyperlipidaemia in most patients within nine months, maintaining normal lipid levels.
    • Dietary intervention did not lead to any regression of xanthelasma plaques.

    Conclusions:

    • Xanthelasma is a potential indicator of underlying hyperlipoproteinaemia, especially Type II.
    • Dietary management is effective in controlling hyperlipoproteinaemia associated with xanthelasma.
    • Low cholesterol diets do not resolve existing xanthelasma lesions, suggesting a need for separate treatment approaches for the skin manifestation.

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