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Nasopharyngeal carcinoma and the EBV-specific T cell response: prospects for immunotherapy
1Cancer Research UK Institute for Cancer Studies, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. leesp@divcs-ex1.bham.ac.uk
Seminars in Cancer Biology
|November 27, 2002
Abstract:
T cells specific for Epstein-Barr virus (EBV) can effectively target the virus-transformed B lymphoproliferative lesions that arise in immunosuppressed transplant patients. This review explores the possibility of developing similar T cell-based strategies to treat an EBV-positive epithelial tumour, nasopharyngeal carcinoma (NPC), which arises in relatively immunocompetent individuals and where EBV antigen expression in the tumour is more limited.