Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromosome 3 linked frontotemporal dementia (FTD-3).

S Gydesen1, J M Brown, A Brun

  • 1Frontotemporal Dementia Research in Jutland Association (FreJA), Denmark.

Neurology
|November 27, 2002
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of dietary phosphorus and calcium depletion-repletion on pig performance and bone quality.

Animal : an international journal of animal bioscience·2026
Same author

Collapse of Nuclear Collectivity along the N=Z Line.

Physical review letters·2026
Same author

Clarifying the N,Z=14 Shells near the Drip Lines from the Spectroscopy of ^{22}Si and ^{21}Al.

Physical review letters·2026
Same author

Safety and use of IBD therapies during pregnancy and lactation.

Expert review of gastroenterology & hepatology·2026
Same author

Bones, reproductive organs and carcass characteristics of entire, early and late immunocastrated male pigs.

Animal : an international journal of animal bioscience·2025
Same author

Efficacy and safety of dupilumab in Hailey-Hailey disease: A multicentre cohort study.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025

This study investigates autosomal dominant frontotemporal dementia (FTD) linked to chromosome 3. The FTD-3 variant shows widespread brain dysfunction, including parietal lobe involvement, and distinct PET scan findings.

Area of Science:

  • Neuroscience
  • Genetics
  • Neuropathology

Background:

  • A large kindred with autosomal dominant frontotemporal dementia (FTD) was identified and studied.
  • The genetic basis for this FTD trait was mapped to the pericentromeric region of chromosome 3.

Observation:

  • Clinical, neuroimaging, neuropsychological, and pathological data were collected over 17 years from 22 affected individuals across three generations.
  • Onset of FTD-3 ranges from 46 to 65 years, presenting with frontal lobe syndrome, temporal and parietal lobe dysfunction, and a late-stage motor syndrome.
  • Neuroimaging revealed generalized cerebral atrophy, with PET scans showing global cerebral blood flow reduction.

Findings:

  • Macroscopic pathology showed preferential frontal lobe atrophy, while microscopic examination revealed neuronal loss and gliosis without specific histopathological features.

Related Experiment Videos

  • FTD-3 shares clinical and pathological characteristics with other FTD forms, meeting international diagnostic criteria.
  • Unlike some FTD subtypes, FTD-3 exhibits significant parietal lobe involvement across clinical, radiological, and pathological assessments.

    • Implications:

    • The diffuse cortical involvement in FTD-3 results in a unique global pattern of reduced cerebral blood flow detected by PET scanning.
    • Understanding FTD-3's distinct features, including parietal lobe involvement, contributes to the broader understanding of frontotemporal dementia heterogeneity.
    • This research highlights the importance of comprehensive phenotyping in characterizing genetic forms of neurodegenerative diseases.