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Relationship between CAG repeat length and late-stage outcomes in Huntington's disease
K Marder1, S Sandler, A Lechich
1Department of Neurology, Sergievsky Center, and The Taub Institute, Columbia University, New York, NY 10032, USA. ksm1@columbia.edu
Neurology
|November 27, 2002
Abstract:
The relationship between CAG repeat length and age at nursing home (NH) admission and age at percutaneous endoscopic gastrostomy (PEG) was examined in 47 residents of a specialized Huntington's disease long-term care facility who were observed for a median of 3 years (range, 1 to 11 years). CAG repeat length was inversely correlated with time to NH admission and PEG (both p < 0.001), independent of age at onset. CAG repeat length may influence disease progression to late-stage outcomes in addition to age at onset.