Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Benzophenone-induced estrogenic potency in ovariectomized rats.

Yoshio Nakagawa1, Kuniaki Tayama

  • 1Department of Toxicology, Tokyo Metropolitan Research Laboratory of Public Health, 3-24-1, Hyakunin-cho, Shinjuku-ku, Japan. yoshio@tokyo-eiken.go.jp

Archives of Toxicology
|November 27, 2002
PubMed
Summary

Benzophenone exhibits estrogenic effects in rats by increasing uterine weight. This activity is mediated by its metabolite, p-hydroxybenzophenone, which possesses intrinsic hormonal properties.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of μ-Opioid Receptor Signaling Responses for Fentanyl Analogs Using Luciferase Complementation Assay.

Biological & pharmaceutical bulletin·2025
Same author

Evaluation of rewarding effects of nitazene analogs: results from conditioned place preference tests and in vivo microdialysis experiments in mice.

The Journal of toxicological sciences·2025
Same author

Cytotoxic effects of psychoactive isobutyrylfentanyl and its halogenated derivatives on isolated rat hepatocytes.

Journal of applied toxicology : JAT·2023
Same author

Hepatic and renal toxicities and metabolism of fentanyl analogues in rats.

Naunyn-Schmiedeberg's archives of pharmacology·2022
Same author

Structure elucidation of a PDE5 inhibitor detected as an illegal adulteration in a libido-boosting dietary supplement.

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment·2020
Same author

A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats.

Journal of toxicologic pathology·2020

Area of Science:

  • Endocrinology
  • Toxicology
  • Pharmacology

Background:

  • Benzophenone is a widely used UV filter.
  • Concerns exist regarding its potential endocrine-disrupting properties.
  • Understanding its estrogenic potency is crucial for risk assessment.

Purpose of the Study:

  • To evaluate the in vivo estrogenic potency of benzophenone.
  • To investigate the role of its metabolites in estrogenic activity.
  • To compare benzophenone's effects with a known estrogen, 17beta-estradiol.

Main Methods:

  • In vivo uterotrophic assay in ovariectomized Sprague-Dawley rats.
  • Oral administration of benzophenone (100 or 400 mg/kg) or 17beta-estradiol (0.2 mg/kg).
  • Measurement of uterine weight, uterine and vaginal epithelium changes, and serum metabolite concentrations.

Related Experiment Videos

Main Results:

  • Benzophenone administration increased uterine weight dose-dependently.
  • Uterine and vaginal tissue changes mirrored those induced by 17beta-estradiol.
  • Serum analysis confirmed the biotransformation of benzophenone to p-hydroxybenzophenone, the likely active metabolite.

Conclusions:

  • Benzophenone demonstrates estrogenic activity in vivo.
  • The estrogenic effects are attributed to its metabolite, p-hydroxybenzophenone.
  • Benzophenone acts as a pro-estrogen, requiring metabolic activation for its hormonal effects.