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Updated: Sep 28, 2026

Quantitative 3D In Silico Modeling (q3DISM) of Cerebral Amyloid-beta Phagocytosis in Rodent Models of Alzheimer's Disease
Published on: December 26, 2016
[Significance of intracellular A beta in Alzheimer's disease]
1National Institute for Longevity Sciences, 36-3, Gengo, Morioka, Obu, 474-8522 Japan.
Abstract:
It is now widely accepted that beta-amyloid has a central role in the pathogenesis of Alzheimer's disease (AD). It is mainly composed of aggregated A beta protein and is deposited in senile plaques and cerebral blood vessels. However, it is not uncommon to see autopsies that reveal significant deposits of beta-amyloid in the brain without manifesting dementia. In fact, several neuropathological studies showed no correlation between beta-amyloid burden and the severity of dementia or loss of synapses. Thus it is questioned whether extracellularly deposited beta-amyloid is directly linked to the Alzheimer pathomechanism. Here I show evidence to support the significance of intraneuronally deposited A beta x-42 by analyzing presenilin 1 transgenic mice and AD patients.
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