Related Experiment Video
Updated: Sep 28, 2026
05:46
Establishing a Diaphyseal Femur Fracture Model in Mice
Published on: December 9, 2022
Effect of insulin-like growth factor-I (IGF-I) on femoral bone modeling in growing mice
Toshitsugu Kawata1, Chiyoko Tokimasa, Tadashi Fujita
1Department of Orthodontics and Craniofacial Developmental Biology, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.
Experimental Animals
|November 28, 2002
Abstract:
The time-dependent effects of daily dosing of IGF-I (1.21 mg/g) on the linear growth of the femur were investigated in mice. The femoral length and volume and the number of osteoclasts were significantly greater after IGF-I injection as compared to the non-injected control, suggesting that the IGF-I imbalance might cause a quick turnover cycle of the bone resulting in the altered femoral modeling.
