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Related Experiment Videos

[Electronmicroscopic studies on solid mammary carcinomas in bitches].

D V Bomhard, R Raddatz

    Zeitschrift Fur Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology
    |January 1, 1975
    PubMed
    Summary

    Electron microscopy revealed distinct intracytoplasmic filaments in canine mammary tumors. These filaments, identified as myoepithelial tumor cells and tonofibrillae, were observed within tumor cells and lymphatic vessels.

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    Annals of the New York Academy of Sciences·1999

    Area of Science:

    • Veterinary Pathology
    • Electron Microscopy
    • Canine Oncology

    Context:

    • Solid mammary carcinomas in female dogs (bitches) present complex cellular structures.
    • Tumor cells within lymphatic vessels indicate potential for metastasis.

    Purpose:

    • To characterize the ultrastructural features of canine mammary carcinomas using electron microscopy.
    • To identify and differentiate specific cell types within these tumors based on intracytoplasmic structures.

    Summary:

    • Electron microscopy of nine canine mammary carcinomas revealed basement membranes surrounding tumor cell cords.
    • Cells with long intracytoplasmic filaments (65 Å thick), presumed myoepithelial tumor cells, were found in five cases.
    • Carcinoma cells in eight tumors exhibited short, randomly arranged intracytoplasmic filaments (tonofibrillae).
    • No viruses or virus-like particles were detected.

    Impact:

    • Provides detailed ultrastructural insights into canine mammary carcinoma pathogenesis.
    • Aids in the differential diagnosis of canine mammary tumors.
    • Contributes to understanding tumor cell differentiation and potential metastatic mechanisms in veterinary oncology.

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