Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human clock genes.

Hugh D Piggins1

  • 1School of Biological Sciences, University of Manchester, UK. hugh.piggins@man.ac.uk

Annals of Medicine
|November 28, 2002
PubMed
Summary
This summary is machine-generated.

Biological clocks regulate daily rhythms in humans, influenced by internal pacemakers and external cues. Understanding core clock genes reveals millions of cellular clocks coordinating physiology and behavior, crucial for well-being.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sex-differential associations of MC3R p.F45S with human metabolic profile.

Journal of neuroendocrinology·2026
Same author

Beyond the barrier: an assessment of social behaviour in mice using a modified 3-chamber test.

Physiology & behavior·2026
Same author

Differential effects of sex and age on daily and infradian rhythms of mice.

The Journal of physiology·2026
Same author

Loss of neuropeptide signalling alters temporal expression of mouse suprachiasmatic neuronal state and excitability.

The European journal of neuroscience·2024
Same author

A novel developmental critical period of orexinergic signaling in the primary visual thalamus.

iScience·2024
Same author

Diverse genetic alteration dysregulates neuropeptide and intracellular signalling in the suprachiasmatic nuclei.

The European journal of neuroscience·2024
Same journal

Effects of sub-anesthetic doses of esketamine on immune function and postoperative negative emotions in acoustic neuroma patients: a randomized clinical trial.

Annals of medicine·2026
Same journal

Postoperative outcomes of on- vs off-pump CABG in patients with HFrEF: a nationwide cohort study in Taiwan.

Annals of medicine·2026
Same journal

Population pharmacokinetic-based dose adjustment of tiapride in patients with impaired renal function.

Annals of medicine·2026
Same journal

Association of neutrophil percentage-to-albumin ratio with sepsis in infant.

Annals of medicine·2026
Same journal

Enhancing Hemoglobin Bart's hydrops fetalis syndrome prevention: a single-tube multiplex real-time PCR assay for the comprehensive detection of four significant α<sup>0</sup>-thalassemia deletions (--<sup>SEA</sup>, --<sup>THAI</sup>, --<sup>CR</sup>, and --<sup>SA</sup>) found in Thailand.

Annals of medicine·2026
Same journal

Association of non-insulin-based insulin resistance indices with the risk of aortic stenosis progression in patients with mild or moderate aortic stenosis.

Annals of medicine·2026
See all related articles

Area of Science:

  • Chronobiology
  • Molecular Biology
  • Genetics

Background:

  • Physiological and behavioral rhythms are governed by internal biological clocks and external environmental factors.
  • Circadian clocks, with periods near 24 hours, are found across diverse organisms, from prokaryotes to humans.
  • Recent advances have elucidated the molecular mechanisms underlying these clocks.

Purpose of the Study:

  • To review the molecular basis of circadian clocks.
  • To highlight the identification of core clock genes and their role in physiological and behavioral rhythms.
  • To discuss the concept of cellular clocks and their implications for health.

Main Methods:

  • Review of scientific literature on circadian rhythms and clock genes.
  • Identification of core clock genes and their human orthologs.

Related Experiment Videos

  • Analysis of feedback models explaining molecular clockworks.
  • Discussion of reporter systems for monitoring clock gene activity.

    • Main Results:

    • Identification of core clock genes and their protein products.
    • Discovery of millions of cellular clocks within the body.
    • Association of polymorphisms in hClock and hPer2 genes with human sleep disorders.
    • Elucidation of coordinated activity of cellular clocks driving physiological and behavioral rhythms.

    Conclusions:

    • The human body comprises millions of coordinated cellular clocks.
    • Appropriate phasing of these clocks with environmental cues is vital for physical and mental well-being.
    • Further research into clock gene function and regulation is essential for understanding health and disease.