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Related Experiment Videos

Acitretin-associated thrombotic stroke.

Bernard Royer1, François Ziegler, Patrice Muret

  • 1Pharmacovigilance and Pharmacology Department, Jean Minjoz University Hospital, Besancon, France. bernard.royer@ufc-chu.univ-fcomte.fr

The Annals of Pharmacotherapy
|November 28, 2002
PubMed
Summary
This summary is machine-generated.

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Acitretin, a psoriasis treatment, may cause thrombotic stroke. This case highlights the need to consider acitretin as a potential cause for unexplained thrombotic events in patients.

Area of Science:

  • Neurology
  • Dermatology
  • Pharmacology

Background:

  • Psoriasis is a chronic inflammatory skin condition.
  • Acitretin is a second-generation retinoid used to treat severe psoriasis.
  • Thrombotic events are a serious potential adverse effect of various medications.

Observation:

  • A 52-year-old woman developed neurological symptoms including nausea, vomiting, vertigo, headaches, and lateropulsion 34 days after starting acitretin for psoriasis.
  • Neurologic examination and MRI revealed cerebellar and bulbar infarcts.
  • MRA confirmed a thrombus in the left vertebral artery.

Findings:

  • The patient's thrombotic stroke was ultimately attributed to acitretin treatment.
  • Differential diagnoses including cardiogenic pathology and coagulopathy were considered but deemed less likely.

Related Experiment Videos

  • This appears to be the first reported case of a thrombotic event associated with acitretin.

    • Implications:

    • Acitretin should be considered a potential cause of thrombotic stroke.
    • Clinicians should maintain a high index of suspicion for acitretin-induced thrombotic events in patients presenting with unexplained thrombotic phenomena.
    • Further research may be warranted to elucidate the mechanism of acitretin-induced thrombosis.