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Meroterpenes from Penicillium sp found in association with Melia azedarach
Regina M Geris dos Santos1, Edson Rodrigues-Fo
1Departamento de Química, Universidade Federal de São Carlos, CP 676, 13 565-905 SP, Brazil.
Phytochemistry
|November 28, 2002
Abstract:
A Penicillium sp was isolated from the root bark of Melia azedarach and cultivated over sterilized rice. After chromatographic procedures, two meroterpenes, named preaustinoid A and B, were obtained in addition to the known alkaloid verruculogen. Their structures were identified by extensive spectroscopic studies, and they exhibited moderate bacteriostatic effects on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus sp.