Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Collateral growth: cells arrive at the construction site.

Claudia Heilmann1, Friedhelm Beyersdorf, Georg Lutter

  • 1Department of Surgery, School of Medicine, Albert-Ludwigs-University Freiburg, Freiburg, Germany.

Cardiovascular Surgery (London, England)
|November 28, 2002
PubMed
Summary

New therapies are needed for end-stage coronary artery disease (CAD) and peripheral artery occlusion disease when bypass surgery isn't an option. This review explores collateral vessel development and key cell types for treating ischemic conditions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of Hydrolyzed Metal Ions and Surfactants on the Phase Transfer of Al<sub>2</sub>O<sub>3</sub>, SiO<sub>2</sub>, and SnO<sub>2</sub>.

Langmuir : the ACS journal of surfaces and colloids·2024
Same author

A cross-sectional survey of German PA employment and workforce entry.

JAAPA : official journal of the American Academy of Physician Assistants·2022
Same author

The <i>Meta</i>-Substituted Isomer of TMPyP Enables More Effective Photodynamic Bacterial Inactivation than <i>Para</i>-TMPyP In Vitro.

Microorganisms·2022
Same author

A brief introduction to PAs in Germany.

JAAPA : official journal of the American Academy of Physician Assistants·2022
Same author

Efficacy of Vascular Closure Devices in Closing Large-Bore Sheath Arterial Sites after Treatment with Extracorporeal Life Support System.

The Thoracic and cardiovascular surgeon·2021
Same author

Brain vulnerability and viability after ischaemia.

Nature reviews. Neuroscience·2021

Area of Science:

  • Cardiovascular Biology
  • Regenerative Medicine
  • Vascular Biology

Background:

  • Coronary artery disease (CAD) and peripheral artery occlusion disease are prevalent, often requiring advanced treatments.
  • End-stage disease limits surgical options like bypass, necessitating alternative therapeutic strategies.
  • Endogenous collateralization, through angiogenesis and arteriogenesis, is a natural response to ischemia.

Purpose of the Study:

  • To review the mechanisms of collateral vessel development in response to ischemia.
  • To highlight the critical roles of monocytes/macrophages and endothelial progenitor cells in collateral circulation.
  • To discuss the therapeutic potential of these cells for ischemic heart and skeletal muscle diseases.

Main Methods:

  • Review of existing literature on collateral vessel formation.

Related Experiment Videos

  • Analysis of cellular and molecular events during angiogenesis and arteriogenesis.
  • Discussion of cell migration and function in ischemic environments.

    • Main Results:

    • Collateral vessel development involves sequential processes including angiogenesis and arteriogenesis.
    • Monocytes/macrophages and endothelial progenitor cells are key circulating cells migrating to ischemic sites.
    • These cells are crucial for promoting vessel growth and restoring blood flow.

    Conclusions:

    • Understanding collateralization mechanisms is vital for developing new treatments for ischemic diseases.
    • Targeting monocytes/macrophages and endothelial progenitor cells offers a promising therapeutic avenue.
    • Cell-based therapies hold potential for treating end-stage cardiovascular and peripheral artery diseases.