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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
08:50

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

[Management of threatening preterm labor with intact membranes: indications for antibiotics]

N Winer1

  • 1Service d'Obstétrique et Médecine Foetale, CHU de Nantes, Hôpital Mère-Enfant, 44093 Nantes, France. norbert.winer@chu-nantes.fr

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|November 28, 2002
PubMed

Insights

Systematic antibiotic therapy is not recommended for preterm labor with intact membranes and no infection symptoms. While it may slightly prolong pregnancy and reduce maternal infection, it offers no neonatal benefits and may increase bacterial resistance.

Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Neonatology

Context:

  • Preterm labor with intact membranes is a common obstetric complication.
  • The role of antibiotic therapy in managing preterm labor is debated.
  • Antenatal infections can significantly impact maternal and neonatal outcomes.

Purpose:

  • To analyze the benefits and disadvantages of systematic antibiotic therapy in patients with preterm labor and intact membranes.
  • To evaluate the impact of antibiotic use on maternal and neonatal outcomes.
  • To determine the efficacy of antibiotics in specific patient groups, including those with asymptomatic bacteriuria or positive vaginal colonization.

Summary:

  • Systematic antibiotic prescription is not advised for preterm labor with intact membranes and no infection symptoms.
  • Antibiotics show minimal benefit in prolonging pregnancy and reducing maternal infection, with no demonstrated advantage for neonatal outcomes.
  • Increased bacterial drug resistance is a risk with antepartum chemoprophylaxis. Local treatments are not recommended. Antibiotics are recommended for asymptomatic bacteriuria, reducing prematurity and maternal infections.

Impact:

  • Findings guide clinical practice regarding antibiotic use in preterm labor, potentially reducing unnecessary antibiotic exposure and associated risks.
  • Highlights the importance of targeted antibiotic treatment for asymptomatic bacteriuria.
  • Informs future research on optimizing antibiotic strategies to improve maternal and neonatal outcomes in preterm labor.
Abstract

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