Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Characterizing the physical genome.

Jonathan R Pollack1, Vishwanath R Iyer

  • 1Department of Pathology, Stanford University School of Medicine, CCSR Building, Room 3245A, 269 Campus Drive, Stanford, California 94305-5176, USA. jpollack1@stanford.edu

Nature Genetics
|November 28, 2002
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erratum to "Establishing and characterizing the molecular profiles, cellular features, and clinical utility of a patient-derived xenograft model using benign prostatic tissues" (Lab Invest 2024 Oct;104(10):102129).

Laboratory investigation; a journal of technical methods and pathology·2026
Same author

Immune repertoire profiling uncovers pervasive T cell clonal expansions in benign prostatic hyperplasia.

The Journal of clinical investigation·2025
Same author

Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice.

eLife·2024
Same author

Establishing and Characterizing the Molecular Profiles, Cellular Features, and Clinical Utility of a Patient-Derived Xenograft Model Using Benign Prostatic Tissues.

Laboratory investigation; a journal of technical methods and pathology·2024
Same author

AZGP1 deficiency promotes angiogenesis in prostate cancer.

Journal of translational medicine·2024
Same author

Spatial transcriptomics identifies candidate stromal drivers of benign prostatic hyperplasia.

JCI insight·2023
Same journal

Mutations in splicing factor gene U2AF1 rescue defective oncogene splicing in KRAS-mutant cancers.

Nature genetics·2026
Same journal

Assessing the effect of immune surveillance on clonal expansions in the blood.

Nature genetics·2026
Same journal

Improved heritability partitioning and enrichment analyses using summary statistics with graphREML.

Nature genetics·2026
Same journal

U2AF1 mutations rescue deleterious exon skipping induced by KRAS mutations.

Nature genetics·2026
Same journal

Lineage tracing from cellular heritage to disease destiny.

Nature genetics·2026
Same journal

Multiomics analysis of primary metabolism reveals the genetic basis of nitrogen partitioning modulated by ZmAVT1A-1 in maize.

Nature genetics·2026
See all related articles

Understanding the physical genome, including DNA and proteins, is key to gene regulation and stability. Microarray methods offer detailed insights into this dynamic structure, complementing gene expression studies.

Area of Science:

  • Genomics and Molecular Biology
  • Epigenetics and Chromosome Biology

Background:

  • The genome is a dynamic physical entity composed of DNA and proteins, organized into chromosomes.
  • Characterizing the physical genome is crucial for understanding fundamental biological processes.

Purpose of the Study:

  • To highlight the relevance of physical genome characterization for understanding gene expression, DNA replication, repair, recombination, chromosome segregation, epigenetic inheritance, and genomic instability.
  • To introduce microarray-based methods as a tool for detailed physical genome analysis.

Main Methods:

  • Utilizing microarray-based methods for detailed physical genome characterization.
  • Complementing physical genome studies with genome-wide mRNA expression profiling.

Main Results:

Related Experiment Videos

  • Microarray methods are beginning to provide a detailed picture of the physical genome.
  • These methods complement existing successful genome-wide mRNA expression profiling studies.

Conclusions:

  • A thorough characterization of the physical genome is essential for advancing our understanding of various cellular processes.
  • Microarray technology offers a powerful approach to achieve this detailed characterization.