Oral therapy for Peyronie's disease

Area of Science:

• Urology and Andrology
• Molecular Biology of Inflammation and Wound Healing

Background:

• Peyronie's disease (PD) presents a significant therapeutic challenge in urology.
• Limited progress has been made in effective oral medical treatments for PD.
• Early-stage PD may respond better to interventions than established plaques.

Purpose of the Study:

• To review historical and contemporary oral medical therapies for Peyronie's disease.
• To discuss promising new approaches in PD management.
• To highlight the need for a definitive oral therapy for PD.

Main Methods:

• Literature review of historical and current oral medical treatments for Peyronie's disease.
• Discussion of emerging therapeutic strategies based on molecular biology insights.

Main Results:

• No definitive oral medical therapy for Peyronie's disease has been established.
• Several novel therapeutic approaches show potential for future success.
• Initial recommendations often include safe, well-tolerated, and inexpensive oral therapies for early-stage disease.

Conclusions:

• Advances in understanding inflammation and wound healing are expected to improve PD management.
• Further research is needed to establish effective and definitive oral treatments for Peyronie's disease.
• A comprehensive review of oral therapies is crucial for guiding clinical practice.