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The strategy of immunologic control of HIV-1 with structured treatment interruptions (STIs)

R B Moss1, F C Jensen, D J Carlo

  • 1Immune Response Corporation, 5935 Darwin Court, Carlsbad, CA 92008, USA.

Current Drug Targets. Infectious Disorders
|November 29, 2002
PubMed

Structured treatment interruptions (STIs) have evolved as an experimental approach of interrupting highly active antiretroviral therapy (HAART) similar to cycles of cancer chemotherapy in order to develop immune control of HIV-1. There are multiple, ongoing clinical trials examining interruptions in antiviral therapy with and without immune-based therapies. If successful in developing immune control, STIs may be clinically useful but require large scale clinical trials to prove their utility and safety.

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