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Human gene therapy: ensuring progress in the next millennium.

D Knorr1

  • 1NIH Office of Recombinant DNA Activities (ORDA), NIH Recombinant DNA Advisory Committee (RAC), USA.

National Forum
|November 29, 2002
PubMed
Summary

The year 2000 marks milestones in gene therapy and recombinant DNA technology. Public concern grew alongside recognition of DNA technology's therapeutic potential.

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Area of Science:

  • Biotechnology
  • Genetics
  • Medical Ethics

Background:

  • The early 1970s saw the rise of recombinant DNA technology.
  • This technology held promise for developing novel therapeutics for severe diseases.
  • Simultaneously, public apprehension grew regarding potential biohazards and health risks.

Purpose of the Study:

  • To commemorate significant anniversaries in biotechnology and human gene therapy.
  • To reflect on the dual nature of technological advancement: therapeutic potential versus public risk.
  • To contextualize the historical development of genetic engineering and its societal implications.

Main Methods:

  • Historical review of key events in biotechnology.
  • Analysis of the societal impact of recombinant DNA technology.
  • Examination of public perception and ethical considerations in genetic research.

Main Results:

  • The year 2000 signifies the 10th anniversary of human gene therapy.
  • The same year marks the 25th anniversary of the Asilomar conference.
  • Recognition of recombinant DNA's therapeutic promise coexisted with public anxiety.

Conclusions:

  • The history of gene therapy and DNA technology is marked by both innovation and public concern.
  • Ethical considerations and risk assessment are crucial in the advancement of biotechnologies.
  • The Asilomar conference was a pivotal moment in addressing safety and ethical issues in genetic engineering.
Keywords:
Genetics and ReproductionNIH Guidelines

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