Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programmed cell death in the developing limb.

Vanessa Zuzarte-Luís1, Juan M Hurlé

  • 1Departamento de Anatomía y Biologia Celular, Facultad de Medicina, Universidad de Cantabria, Santander, Spain.

The International Journal of Developmental Biology
|November 29, 2002
PubMed
Summary

Programmed cell death, crucial for limb development and tail regression in tadpoles, is a physiological process. Historical studies in developing limbs revealed its genetic control, though molecular aspects are now gaining attention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retinoic acid regulates the proliferation, differentiation, and cell death of limb skeletal progenitors, contributing to establish the size and identity of the digits.

EvoDevo·2025
Same author

CSP ubiquitylation favours Plasmodium berghei survival during early liver stage infection.

Scientific reports·2025
Same author

Lysosomes, caspase-mediated apoptosis, and cytoplasmic activation of P21, but not cell senescence, participate in a redundant fashion in embryonic morphogenetic cell death.

Cell death & disease·2023
Same author

A non-canonical sensing pathway mediates Plasmodium adaptation to amino acid deficiency.

Communications biology·2023
Same author

Modeling the Differentiation of Embryonic Limb Chondroprogenitors by Cell Death and Cell Senescence in High Density Micromass Cultures and Their Regulation by FGF Signaling.

Cells·2023
Same author

A spatiotemporally resolved single-cell atlas of the Plasmodium liver stage.

Nature·2022

Area of Science:

  • Developmental Biology
  • Cell Biology

Background:

  • Programmed cell death is a fundamental physiological process in multicellular organisms.
  • Limb development and anuran tadpole tail regression are key model systems for studying programmed cell death.
  • Early research established the concept and genetic control of cell death in developing limbs.

Purpose of the Study:

  • To review current information on the control of programmed cell death during limb development.
  • To highlight the historical significance of limb development in understanding programmed cell death.
  • To encourage further molecular investigation into limb tissue regression.

Main Methods:

  • Comparative analyses of cell death patterns in avian species (chick vs. duck interdigits).
  • Examination of cell death in chick mutants with varying limb phenotypes.

Related Experiment Videos

  • Review of recent molecular studies on apoptosis in limb development.

    • Main Results:

    • Developing limbs and tadpole tail regression are paradigmatic examples of programmed cell death.
    • Comparative and mutant studies provided early evidence for genetic control of cell death.
    • Despite historical importance, limb development's molecular control of apoptosis has been understudied until recently.

    Conclusions:

    • Programmed cell death is a vital physiological process, exemplified by limb sculpting and tail regression.
    • Limb development research has historically been pivotal in understanding cell death.
    • Further molecular research on limb programmed cell death is warranted to advance understanding of tissue regression.