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Adiponectin in essential hypertension.
Francesca Mallamaci1, Carmine Zoccali, Fortunata Cuzzola
1CNR, Center of Clinical Physiology, Reggio Calabria, Italy.
Journal of Nephrology
|November 29, 2002
Summary
Plasma adiponectin (ADPN) levels are higher in hypertensive men and inversely related to renal function in essential hypertension. These findings suggest ADPN may counteract cardiovascular risks associated with high blood pressure.
Area of Science:
- Endocrinology
- Nephrology
- Cardiovascular Medicine
Background:
- Adiponectin (ADPN) is a key adipose tissue protein.
- Reduced ADPN synthesis is linked to endothelial dysfunction and cardiovascular diseases.
- The role of ADPN in essential hypertension requires further investigation.
Purpose of the Study:
- To examine the relationship between plasma ADPN levels, body mass index (BMI), fat mass, and renal function in patients with essential hypertension.
- To determine if sex influences these relationships.
Main Methods:
- Studied 36 patients with uncomplicated essential hypertension.
- Measured plasma ADPN, BMI, fat mass (BIA), creatinine clearance, serum insulin, and HOMA-R index.
- Utilized multiple regression analysis to identify independent predictors of plasma ADPN.
Main Results:
- Plasma ADPN was higher in hypertensive patients than normotensive subjects (P=0.06).
- Hypertensive men showed significantly higher plasma ADPN than normotensive men (P=0.01).
- Plasma ADPN was inversely related to creatinine clearance in hypertensive patients, with creatinine clearance being the sole independent predictor.
Conclusions:
- Plasma ADPN levels in essential hypertension are influenced by sex and renal function.
- Elevated ADPN in hypertensives may represent a compensatory mechanism against endothelial damage and cardiovascular risk.