Gas chromatographic method for the determination of nomifensine in human plasma

An analytical method based on solvent extraction, formation of a fluorinated derivative and quantitation by gas-liquid chromatography using an electron capture detector has been developed for the determination of nomifensine in biological fluids. The specificity (controlled by mass spectrometry) and the sensitivity appear to be satisfactory for drug level measurements in human body fluids. Its relative simplicity in fact permits its use in serial analysis.