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Related Experiment Videos

Early increase and later decrease in VIP and substance P nerve fiber densities following abdominal radiotherapy: a

U Höckerfelt1, L Franzén, O Norrgård

  • 1Department of Integrative Medical Biology, Section for Anatomy, Umeå University, SE-901 87 Umeå, Sweden.

International Journal of Radiation Biology
|November 29, 2002
PubMed
Summary
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Abdominal irradiation initially increases substance P (SP) and vasoactive intestinal peptide (VIP) nerve fibers in the colon but decreases them long-term. This change in neuropeptide innervation may affect gut function after radiotherapy.

Area of Science:

  • Gastroenterology
  • Neuroscience
  • Oncology

Background:

  • Neuropeptides substance P (SP) and vasoactive intestinal peptide (VIP) are crucial for intestinal motility and inflammation.
  • These peptides are upregulated during tissue stress, such as following abdominal irradiation.

Purpose of the Study:

  • To quantify mucosal and smooth muscle SP, VIP, and total innervation in the human colon.
  • To assess these changes in both short-term and long-term perspectives after abdominal irradiation.

Main Methods:

  • Immunohistochemistry and computerized image analysis were used on colon specimens from irradiated and non-irradiated patients.
  • Plasma levels of SP and VIP were analyzed in patients undergoing radiotherapy.

Main Results:

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  • Short-term (4-7 days) post-irradiation showed increased overall innervation, SP, and VIP nerve fiber densities in the colon's mucosa and muscle layers.
  • Long-term (5-6 weeks and years) post-irradiation revealed decreased SP and VIP nerve fiber densities.
  • No significant changes in plasma SP or VIP levels were observed.

Conclusions:

  • Radiotherapy initially increases SP and VIP innervation in the colon, potentially influencing inflammation and motility.
  • Long-term reduction in SP and VIP neuronal supply may contribute to intestinal dysfunction after radiation therapy.
  • The findings suggest a dynamic role for neuropeptides in the gut's response to abdominal irradiation.