Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chromatin dynamics and DNA repair.

Tsuyoshi Ikura1, Vasily V Ogryzko

  • 1Research Institute for Radiation Biology and Medicine, Department of experimental oncology, Hiroshima University, Hiroshima 734-8553, Japan.

Frontiers in Bioscience : a Journal and Virtual Library
|November 29, 2002
PubMed
Summary

DNA repair requires changes to chromatin structure, but these changes must be temporary. Improper chromatin maintenance after DNA repair may contribute to aging and disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Persistent Homology Approach Enables Single-Cell Detection of Chromatin Spatial Organization Changes During Pathological Senescence Transition.

Genes to cells : devoted to molecular & cellular mechanisms·2026
Same author

Acetylation-Dependent Histone H2AX Exchange Suppresses Pathological Senescence via MDC1 Degradation.

Molecular and cellular biology·2026
Same author

A multifunctional enzyme: commentary on 'structure-specific DNA endonuclease T7 endonuclease I cleaves DNA containing UV-induced DNA lesions'.

Journal of biochemistry·2025
Same author

Machine Learning Extracts Radiation Resistant-Specific EdU Fluorescence Pattern in Cancer Cells.

Genes to cells : devoted to molecular & cellular mechanisms·2025
Same author

Positive coactivator PC4 shows dynamic nucleolar distribution required for rDNA transcription and protein synthesis.

Cell communication and signaling : CCS·2025
Same author

Autophagy promotes the acquisition of genotoxic resistance in cancer cells in a paracrine manner via upregulation of PLK1-RAD9A axis.

Journal of biochemistry·2025

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Eukaryotic genome packaging into chromatin presents challenges for DNA repair accessibility.
  • Chromatin structure must be dynamically altered to permit DNA repair processes.
  • Understanding chromatin modification's role in DNA repair is crucial.

Purpose of the Study:

  • To investigate the dynamic interplay between chromatin structure and DNA repair mechanisms.
  • To explore how chromatin modifications facilitate DNA repair within the chromatin context.
  • To examine the requirement for transient chromatin changes during DNA repair and their maintenance.

Main Methods:

  • The abstract does not specify methods.

Main Results:

  • Chromatin accessibility is a key challenge for DNA repair machinery.
  • Chromatin modifying mechanisms are being identified for their role in DNA repair.
  • Transient chromatin alterations are necessary for successful DNA repair.

Conclusions:

  • Proper maintenance of chromatin states post-repair is essential.
  • Defects in chromatin state maintenance after repair may link to aging and pathologies.

Related Experiment Videos