Creating polyketide diversity through genetic engineering
1Kosan Biosciences, 3832 Bay Center Place, Hayward, CA 94545, USA. kealey@kosan.com
Abstract:
Modular polyketide synthases (PKS) are large multifunctional enzymes that synthesize complex polyketides, a therapeutically important class of natural products. The linear order and composition of catalytic sites that comprise the PKS represent a "code" that determines the identity of the polyketide product. By re-programming the PKS through genetic engineering, it is possible to alter the code in a predictable manner to create specific structural modifications of polyketides and to produce new libraries of these natural products.
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